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What To Do If I Am Not Getting Results Using Minoxidil? A topical medication called minoxidil can be applied straight to the scalp. It is often administered twice a day. A topical drug called minoxidil is applied straight to the scalp. It is intended to be used twice a day. The majority of people who use minoxidil often apply it twice daily, once in the morning and once in the evening, usually just before bed. There are various easy-to-use types of minoxidil available. We've outlined how to apply minoxidil liquid and foam below to cure hair loss. We have also covered the fundamentals of minoxidil's mechanism of action in treating hair loss. Making use of minoxidil is easy. Apply the minoxidil solution or foam as directed above to your scalp.